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PHỤ LỤC 1

Định lượng alkaloid tồn phần trong cao chiết ethanol cải cần

Cân chính xác khoảng 1,000 g cao cải cần, thêm 30 ml dung dịch acid

sulfuric 2%, siêu âm trong 15 phút. Lọc dung dịch acid này qua bông, rửa bông

bằng 5 ml dung dịch acid sulfuric 2%. Gộp dịch chiết và dịch rửa. Kiềm hóa

dịch acid này bằng ammoniac đậm đặc đến pH 10. Sau đó chiết bằng chloroform

5 lần, mỗi lần 10 ml. Gộp toàn bộ dịch chiết chloroform, làm khan nước bằng

natri sulfat khan, lọc vào chén đã sấy khô và cân bì trước, rửa natri sulfat bằng 5

ml chloroform rồi lọc vào chén cân, bốc hơi chloroform trên cách thủy đến cắn.

Sấy cắn ở 100℃ đến khối lượng không đổi.

Hàm lượng alkaloid tồn phần trong cao CC được tính theo cơng thức:

mcắn

X=



mcao x (100 –



x 10000 (%)



acao)

Trong đó: X: hàm lượng alkaloid toàn phần trong cao

chiết cải cần (%)

mcắn: khối lượng cắn alkaloid toàn phần (g).

mcao: khối lượng cao chiết (g).

acao: độ ẩm cao chiết (g).



PHỤ LỤC 2

Kết quả định lượng hàm lượng alkaloid tổng số trong cao chiết cồn

Sau khi tiến hành định lượng kết quả được trình bày ở bảng a.

Bảng a. Hàm lượng alkaloid toàn phần trong cao CC.

Lần thí



Độ



Khối



Khối lượng



Hàm lượng



M ± SD



nghiệm



ẩm



lượng



cắn alkaloid



alkaloid tồn



(%)



(%)



cao (g)



tồn phần (g)



phần (%)



1



11,65



1,012



0,038



4,25



2



11,65



1,015



0,036



4,01



3



11,65



1,013



0,037



4,13



4,02



4



11,65



1,003



0,034



3,84



± 0,17



5



11,65



1,009



0,034



3,81



6



11,65



1,005



0,036



4,05



Như vậy, hàm lượng alkaloid toàn phần trong cao chiết cồn từ cải cần

khoảng 4,02% tính theo chế phẩm khô kiệt.